국소적인 불소도포제재와 불소유리 치면열구전색재의 내산성 효과
ANTICARIOGENIC EFFECT OF FLUORIDE RELEASED FROM SEALANT COMPARED TO TOPICAL FLUORIDE APPLICATION METHODS
소속 상세정보
박기태/Kitae Park
손흥규/최병재/박광균/손동수/이종갑/Heung-Kyu Shon/Byung-Jai Choi/Kwang-Kyun Park/Dong-Su Shon/Jong-Gap Lee
KMID : 0358919970240010148
Abstract
결론
불소유리 치면열구 전색재로부터 유리된 불소 및 국소적인 불소도포 방법이 법랑질의 내
산성효과에 미치는 영향을 total fluoride amount와 firmly-bound fluoride의 관점에서 불소
의 흡수량 및 acid biopsy에 의한 법랑질 탈회정도를 비교하여 다음과 같은 결론을 얻었다.
1. CaF2의 형성은 APF, NaF, fluoride-releasing sealant 도포군에서 모두
관찰되었다.
2. 국소적인 불소도포 방법인 APF 및 NaF에 의해서 법랑질에 흡수되는 불소의 양이 뚜
렷하게 증가된 반면 fluoride-releasing sealant 도포군의 경우 흡수된 불소량의 증가를 관찰
할 수 없었다.
3. APF, NaF도포군 및 불소유리 치면열구 전색재군에서 firmly-bound fluoride의 증가를
관찰할 수 없었다.
4. 법랑질의 내산성은 APF 및 NaF도포군에서 뚜렷하게 향상되었으나 fluoride-releasing
sealant도포군의 경우 특별한 영향을 미치지 않았다.
5. 법랑질에 존재하는 총불소의 절대량과 법랑질의 탈회정도 사이에는 유의한 상관관계를
보이지 않았으며 firmly-bound fluoride의 절대량과 법랑질의 탈회정도사이에도 상관관계는
발견되지 않았다.
이상의 결과로 보아 국소적인 불소도포방법에 의해서만 법랑질의 내산성을 증가시킬 수
있으나 불소유리 치면열구 전색재의 경우에도 전자현미경상에서 CaF2의 형성
이 뚜렷하게 관찰되었으므로 장기적으로 법랑질 표면과 접촉되는 fluoride-releasing sealant
의 경우에도 내산성의 향상을 기대할 수 있다고 생각된다.
#초록#
Sixty human premolar teeth were used for this in vitro study. After each tooth was
sectioned mesiodistally, one half was used for the experimental group and the other half
for the control.
Three group were made for each fluoride applying method and twenty teeth were
assigned to each group.
Ten teeth were used for evaluating total fluoride amount and the other ten were used
for firmly-bound fluoride. Fluoride was used for fluoride-releasing sealant and 1.23%
APF, 0.05% NaF were used for topical application fluorides.
Each tooth was cleaned with a tooth brush using nonfluoride containing pumice before
the experiment.
In the sealant group, fluoroshield was applied to the enamel surface without etching
procedure and stored in 37℃ saline for 30 days.
After 30 days, sealant was removed with explorer without scratching the enamel
surface and washed with distilled wrote. and dried. In the APF group, each tooth was
immersed in 1.23% APF for 30 min then washed and dried in the same manner. In the
NaF group, each tooth was immersed in 0.05% NaF for 24 hours then washed and dried
as described above. After each fluoride regimen was applied, ten teeth were randomly
selected from each group and immersed in 1M KOH solution for 24 hours to remove
loosely-bound floride possibly deposited by the three different fluorides applied. In each
group, total fluoride amount deposited and the amount of enamel removed by acid
biopsy were calculated. After loosely-bound fluride was removed, firmly bound fluoride
deposited and the amount of enamel removed by acid biopsy were also calculated.
Total fluoride amount deposition was significantly increased in the APF and NaF
groups, but not in the sealant group. Amount of enamel removed by acid-biopsy was
also significantly diminished in the APF and NaF group, but not in the sealant group.
After loosely-bound fluoride was removed from each groups, nostatistical difference was
found in the amount of firmly-bound fluoride in any groups. Also no effect of
firmly-bound fluoride on enamel dissolution was shown in any groups after
loosely-bound fluoride was removed from each group.
In conclusion, topical application method of APF or NaF is more effective than
fluoride-releasing sealant application to make CaF2 coating on enamel
surface and CaF2 coating is the main source for anticariogenic effect of
fluoride. However, longterm anticariogenic effect of fluoride-releasing sealant should be
further evaluated.
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